Humalog 100UL/ml 3ml cartridge
1 pcGeneric
Insulin Lispro
Indications
Insulin Lispro is an insulin analogue used to manage hyperglycemia in people with diabetes mellitus. Lispro insulin has a faster onset and a shorter duration of action than conventional human insulin. Insulin Lispro should be administered in combination with a longer-acting insulin in people with type 1 diabetes. When taken in combination with sulfonylurea medications, Insulin Lispro can be utilized without a longer-acting insulin in people with type 2 diabetes.
Pharmacology
Insulin Lispro (insulin lispro, rDNA origin) is a rapid-acting, parenteral blood glucose-lowering medication that is derived from human insulin. It is a Lys(B28), Pro(B29) human insulin analogue, which is generated by reversing the amino acids at positions 28 and 29 on the insulin B-chain. Insulin Lispro is produced in a specific non-pathogenic laboratory strain of Escherichia coli bacterium that has had the gene for insulin lispro added to its genome. Insulin lispro lowers blood glucose levels by facilitating glucose uptake following insulin binding to receptors on muscle and fat cells, as well as inhibiting glucose production from the liver.
Dosage & Administration
Adult: SC Dosing regimen should be individualised and adjusted based on patient's glycaemic response. Usual range is 0.5-1 unit/kg/day.
Type 1 diabetes mellitus: Approximately one third of the total daily insulin requirements SC; rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirements
Usual daily maintenance range: 0.5-1 unit/kg/day in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.8-1.2 units/kg/day
Type 2 diabetes mellitus: If inadequately controlled with oral medication: 10 units/day SC (or 0.1 -0.2 unit/kg/day) of intermediate- or long-acting insulin given at bedtime generally recommended; as an alternative, rapid-acting formulations, such as insulin lispro, given before meals have also been used; dose must be adjusted carefully.
Interaction
Insulin requirements can be increased by drugs with hyperglycemic activity such as corticosteroids, isoniazid, certain lipid-lowering drugs (eg, Niacin), estrogens, oral contraceptives, phenothiazines, and thyroid replacement therapy. Insulin requirements may increase in the presence of medications that increase insulin sensitivity or have a hypoglycemic effect, such as oral antidiabetic medications, salicylates, sulfonamides, certain antidepressants (monoamine oxidase inhibitors), angiotensin converting enzyme inhibitors, blockers of angiotensin II receptors, beta blockers. Inhibitors of pancreatic function (eg, octreotide) and alcohol. Beta-adrenergic blockers can mask hypoglycemic symptoms in some patients.
Contraindications
Insulin Lispro is contraindicated by patients hypersensitivity to insulin lispro or the other excipients.
Side Effects
Clinical studies comparing insulin lispro with normal human insulin showed no difference in the incidence of side effects between the two treatments. Side effects commonly associated with human insulin therapy include: Body in general: allergic reactions. Skin and extremities: injection site reaction, lipodystrophy, pruritus, rash. Other: hypoglycemia.
Pregnancy & Lactation
Category B of pregnancy. All pregnancies have a background risk for birth defects, loss, or other side effects, regardless of drug exposure. This background risk increases in pregnancies complicated by hyperglycemia and can be reduced with good metabolic control. For people with diabetes or a history of gestational diabetes, it is important to maintain good metabolic control before conception and during pregnancy. In patients with diabetes or gestational diabetes, insulin needs may decrease during the first trimester, generally increase during the second and third trimesters, and decrease rapidly after delivery. Careful monitoring of glucose control is essential in these patients. Therefore, patients should be advised to inform their physician if they are planning to become pregnant or if they become pregnant while taking insulin lispro.
Nursing Mothers: It is unknown whether insulin lispro is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when administering insulin lispro to a breastfeeding woman. Insulin lispro is compatible with breastfeeding, but breastfeeding diabetic women may need to have their insulin dose adjusted.
Precautions & Warnings
Kidney or liver dysfunction; Pregnancy, breastfeeding; Change from another insulin. Monitor serum glucose, potassium, electrolytes, HbA1c, and lipid profile. Comorbidities, especially infections.
Therapeutic Class
Rapid Acting Insulin
Storage Conditions
Store at 2°C - 8°C in a refrigerator. Do not freeze. In case of insulin for recent use need not be refrigerated, try to keep it in a cool place and keep away from heat and light. The insulin in use can be kept under the room temperature for a month.
Pharmaceutical Name
Healthcare Pharmaceuticals Ltd.
(Mfg. by: Eli Lilly and Company)